 |
Boston - In patients with prostate cancer, hormone therapy can increase its main therapeutic efficacy of radiotherapy. But if patients with prostate cancer that had a history of heart disease, hormone therapy is dangerous because it can increase the risk of death.
It was concluded in a study published online in the International Journal of Radiation Oncology Biology Physics official scientific journal of ASTRO. According to the study, prostate cancer patients who have heart disease, including those most at risk of hormone therapy.
Research conducted from 1991 to 2006 was observed the 14 594 men with prostate cancer who were treated using radiation therapy with brachytherapy. Of these, 1,378 or about 9.4 percent had a history of heart failure.
style="text-align: justify;">Among people with heart disease conditions, 22.6 percent received supplemental external beam therapy radiation and 42.9 percent receive androgen deprivation therapy for four months. Androgen deprivation therapy is done to reduce the levels of testosterone in the body so that it can slow the growth of cancer.
In the group of men for prostate cancer with a history of heart disease, the addition of hormone therapy led to a significant increase of the level of risk of death. Prostate cancer in men who already have heart disease, researchers found that within 5 years of 31.8 percent of men who received hormone therapy died. While prostate cancer in men who did not receive hormone therapy, only 19.5 percent died.
"We found that in men with localized prostate cancer and a history of heart disease, treatment with hormone therapy plus radiation associated with higher mortality compared to treatment with radiation alone," said Paul L Nguyen, MD, lead author of the study and a radiation oncologist at the Dana-Farber / Brigham and Women's Cancer Center in Boston, as quoted by ScienceDaily.
Further research is needed to understand the mechanism of this effect. For a while, the researchers suggested that prostate cancer patients who have a history of heart disease consult with their doctor first if you want to use hormone therapy.
0 Response to "Hormone Therapy for Patients with Heart Disease Danger"
Posting Komentar