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The body has a biological clock that controls the body what to do naturally. The biological clock controls when the body to rest, need food or other activities performed during 24 hours. Damage to the biological clock can damage the brain.
For the first time, scientists at Oregon State University found that disruption of the biological clock can accelerate brain cell damage, loss of motor function and premature death.
"Currently, many researchers are interested in the study of the biological clock or circadian rhythm, so also we are interested in learning about the various problems that can occur when the biological clock disturbed. In the end, we hope that this research can be taken from the laboratory and applied to life real, "said the researcher, as reported Scienceagogo.com Kuntol Rakshit, Monday (01/16/2012).
The study, published in the journal Neurobiology of Disease is carried out on fruit flies because it has some similarity with human genes. Some of the genes that regulate circadian rhythms in fruit flies have in common with humans, although it has gone through the process of evolution millions of years.
The biological clock in
humans and other animals affect various biological processes, from fertility to hormone production, diet, DNA repair, sleep, stress reactions and even the effectiveness of the drug. In humans, researchers have found a strong relationship between the biological clock mechanisms are disrupted by aging and neurological diseases such as Alzheimer's disease (severe memory lost).
Fruit flies are used in this study had undergone two mutations, one of the mutations disrupt circadian rhythms and other mutations cause the fly brain disease due to aging.
Double mutant flies that had a 32-50 percent shorter lifespan, lost much of motor function and experience vacuoles (holes in the brain) is much faster than flies with good biological clock. Researchers speculate that disruption of the biological clock that caused the damaging effects.
"The decline and loss of function of the biological clock may be just the beginning of a process cycle of destructive. When the biological clock begins to break down, rhythms that regulate cell function and health so disturbed and we now know that this triggers a nerve cell damage in the brain, which can lead to more a lot of damage to the function of the biological clock, "explained co-researcher, Jadwiga Giebultowicz.
The researchers believe that a healthy biological clock can help protect against this damage.
"When the biological clock was broken, the damage process is accelerated. The aging process is closely associated with this process, but it is not clear how the process. Finding a way to restore the biological clock may be a treatment to prevent damage to the biological clock and help prevent progression of the disease," said Giebultowicz.
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