 |
Despite thousands of years old, malaria is even more difficult to overcome because it appears resistance to existing drugs. The medicine can no longer be used and instead spread the malaria parasite.
Until then a team of researchers from several countries, including the Eijkman Institute, Hasanuddin University and the University of Melbourne found there a drug that can stop the spread of drug resistance in malaria parasites.
The medicine is called atovaquone. Released in 2000, its popularity dimmed so the issue of drug resistance in malaria spread.
To prove this, the researchers have also been observed in the life cycle of the malaria parasite in the body of rats and mosquitoes. As a result, researchers can ensure the formation and spread of resistance in these parasites.
When dipapari with atovaquone, most successful parasites have a genetic mutation that makes shielded from the effects of the drug. But after that the life cycle stagnates or impaired.
According to researchers, these drugs can change the process of the parasite to gain energy or 'food source'. Not only that, the resistance that had also stopped in the parasite alone, can not be distributed again.
Proved after researchers conducted 44 times the effort spread of resistance of malaria parasites that live in the body of one mouse to another, success is only recorded once. In other words, these drugs successfully 'trap' the order not to spread the malaria parasite resistance to drugs of the same.
"Now we understand that tertentulah genetic mutations that raise their resistance to certain malaria parasite population, but from this study we found a new way to control it," said research team leader Professor Geoff McFadden reports the BBC.
His team has also been conducting trials on a malaria parasite that normally resides in the human body, and found similar results. Nevertheless, future researchers still want to do a field test by taking him all the way to Kenya and Zambia.
Unfortunately, despite atovaquone declared safe for pregnant women and children, the price is still not friendly on the pocket of the developing world.
This study also involved researchers from the University of Jichi, Nagasaki University and the University of Tokyo, Japan, and the US Johns Hopkins University.
0 Response to "Review the Legacy Drugs, Researchers fact Discover absorbers Resistance in Malaria"
Posting Komentar