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Rome, Italy - Food could be activating molecules in the brain. Researchers found eating too much can cause brain aging while eating little can activate molecules that help keep the brain young. Researchers suggest eat 70 percent of the portion not all.
Activation of the molecule to the diet discovered by Italian scientists. Researchers find molecule that is activated by a brain food can make longevity.
The team of researchers at the Catholic University of Sacred Heart in Rome, Italy, have found that the active molecule called CREB1 is triggered by calorie restriction when eating. CREB1 activates many genes associated with aging and brain function.
CREB1 is the molecule that is activated by calorie restriction and activates other molecules associated with longevity 'sirtuins'. CREB1 is known to have an important function for the brain's ability to remember, organize the process of learning and anxiety and reduce aging.
"Our hope is to find a way to activate CREB1, for example through new drugs, so as to keep the brain young without the need of a strict diet," said Dr. Giovambattista Pani, researcher at the Institute of General Pathology, Faculty of Medicine at the Catholic University of Sacred Heart in Rome as MedicalXpress.com reported.
Calorie restriction research is done intensively in mice. Caloric restriction means the animals can only eat up to 70 percent of the foods commonly consumed and is a known experimental way to extend life.
Usually, the calorie intake is restricted mice do not become obese, do not have diabetes, have a better memory and less aggressive. Furthermore, these mice did not experience Alzheimer's disease and had fewer symptoms than mice that glut.
For humans, this amount is equal to about 600 calories per day. A cup of tea or coffee can also be beneficial, because the study also showed that caffeine increased the amount of CREB1 made in the body.
The study also found that the lack CREB1 in mice eliminate the benefits of calorie restriction in the brain. Thus, animals without CREB1 show the same brain damage such as stuffed animals or old.
Unfortunately, in a report published Proceedings of the National Academy of Sciences USA (PNAS), researchers still have not managed to find out the exact molecular mechanism behind the positive effect of the low-calorie foods.
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